Drugs efficacy evaluations
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OSTEOARTHRITIS BIOMARKERS
During the past years, a major step forward has been done in the clinical use of osteoarthritis biomarkers.

New measurement technologies have been developed and several biomarkers were identified.
BIOCHEMICAL BIOMARKERS
FOR THE EVALUATION OF OSTEOARTHRITIS
CTX-II
C-Terminal telopeptide of collagen type II
α-CTX-II
Type II collagen α chains collagenase neoepitope
PIINP
Type II collagen propeptides
C2C
Type II collagen cleavage product
C2M
Collagen type II-specific neoepitope
CTX-I, α-CTX-I
C-terminal telopeptide of collagen type I
PINP
Aminoterminal propeptide of collagen type I
C1,C2
Types I and II collagen cleavage neoepitope
 
Chondroitin sulfate epitope 846
COMP & D-COMP
Cartilage oligomeric matrix proteins
FSTL-1
Follistatin-like protein 1
Hyaluronic Acid
Hyaluronan
MMP-1, MMP-3, MMP-9, MMP-13 and TIMPs
Matrix metalloproteinases
hs-CRP, IL-1β and IL-6
Inflammatory biomarkers
Adiponectin, Leptin
Adipokines
sOB-Rb
Soluble receptor for leptin
Periostin
Cellular interactions in bone
DKKs and SOST
Wnt inhibitors
 
Uric acid

Legend of abbreviations

COMP
Cartilage oligomeric protein
COX-2
Cyclo-oxygenase-2
hs-CRP
High sensitivity C reactive protein
IL
Interleukin
MMP
Matrix metalloproteinase
PIINP
N-propeptide II of type II collagen
SOST
Sclerostin
TIMP
Tissue inhibitor of matrix metalloproteinase